Does Melatonin affect Blood Pressure?

Melatonin and Blood Pressure

Cardiovascular diseases accounts for one third of the population where hypertension has hit approximately 9.4 million deaths globally. Melatonin also known as N-acetyl-5-methoxytryptamine is a circadian hormone, which is clinically used as effective hypertensive agent. Melatonin production declines with age. Clinical trials with disorders like type 2 diabetes along with insulin resistance and hypertension, exogenous melatonin administration significantly improved hypertension condition.

Cardiac events like myocardial infarction, sudden cardiac death and cardiac arrhythmias increases in the early morning, when circulating melatonin levels are considerably found lower. There are clinically proven research papers that has shown that low melatonin secretion levels are associated with a greater risk of incidence for myocardial infarction especially in women with increased body mass index.

Patients with metabolic syndrome and obesity, melatonin supplementation of 5 mg/day, 2 hours before bedtime for two months reduced the systolic and diastolic blood pressure and low-density lipoprotein cholesterol (bad cholesterol)

Melatonin affect Blood Pressure

Consuming melatonin-rich foods such as grape juice, red wine, cereals, fruits and walnuts increases circulating melatonin levels and antioxidant capacity. Preclinical studies suggest that melatonin when given at dietary levels, confers cardio protection.

In a randomized, double-blind, placebo-controlled, trial ,16 men with untreated essential hypertension were investigated repeatedly daily for 3 weeks with oral melatonin of 2.5 mg intake, 1 hour before sleep on 24-hour ambulatory blood pressure which proved that repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6- and 4-mm Hg, respectively. The treatment did not affect heart rate.

Most promising results were achieved in patients with non-dipping night time pressure, in which the circadian rhythm of BP variation is disturbed. Melatonin may act on Blood Pressure also via specific melatonin receptors localized in peripheral vessels or in parts of CNS (central nervous system) participating in BP control.

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REFERENCES:

https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.12942
https://www.frontiersin.org/articles/10.3389/fphys.2018.00528/full
https://pubmed.ncbi.nlm.nih.gov/14732734/
https://pubmed.ncbi.nlm.nih.gov/17439547/

Geeta Bhatia Thorat

-Expert and Writer

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